McAfee On-Access Scan cannot be enabled [Suspect Malware]

On startup, McAfee automatically disables the On-Access Scan option and it cannot be enabled.
Here is the log:

Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 16:12:30, on 02/11/2009
Platform: Windows XP SP3 (WinNT 5.01.2600)
MSIE: Internet Explorer v8.00 (8.00.6001.18702)
Boot mode: Normal

Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\Program Files\Windows Defender\MsMpEng.exe
C:\WINDOWS\System32\svchost.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\system32\spoolsv.exe
C:\WINDOWS\system32\dllhost.exe
C:\WINDOWS\system32\inetsrv\inetinfo.exe
C:\Program Files\Common Files\InterVideo\RegMgr\iviRegMgr.exe
C:\Program Files\McAfee\VirusScan Enterprise\EngineServer.exe
C:\Program Files\McAfee\Common Framework\FrameworkService.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\McAfee\VirusScan Enterprise\VsTskMgr.exe
C:\Program Files\Microsoft SQL Server\MSSQL.3\MSSQL\Binn\msftesql.exe
C:\Program Files\Microsoft SQL Server\MSSQL.3\MSSQL\Binn\sqlservr.exe
C:\Program Files\PDF Complete\pdfsvc.exe
C:\Program Files\Microsoft SQL Server\90\Shared\sqlwriter.exe
C:\WINDOWS\system32\igfxtray.exe
C:\WINDOWS\system32\hkcmd.exe
C:\WINDOWS\system32\igfxsrvc.exe
C:\WINDOWS\system32\igfxpers.exe
C:\Program Files\Analog Devices\Core\smax4pnp.exe
C:\Program Files\Analog Devices\SoundMAX\Smax4.exe
C:\WINDOWS\SMINST\Scheduler.exe
C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe
C:\Program Files\Java\jre1.5.0_06\bin\jusched.exe
C:\Program Files\Microsoft Office Communicator\communicator.exe
C:\Program Files\Windows Defender\MSASCui.exe
C:\WINDOWS\system32\ctfmon.exe
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe
C:\WINDOWS\system32\wuauclt.exe
C:\WINDOWS\system32\mmc.exe
C:\WINDOWS\system32\dllhost.exe
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\Program Files\McAfee\Common Framework\UdaterUI.exe
C:\Program Files\McAfee\Common Framework\McTray.exe

R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://intranet.isd.icscomputing.co.uk/default.aspx
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://go.microsoft.com/fwlink/?LinkId=69157
O2 - BHO: Groove GFS Browser Helper - {72853161-30C5-4D22-B7F9-0BBC1D38A37E} - C:\Program Files\Microsoft Office\Office12\GrooveShellExtensions.dll
O2 - BHO: SSVHelper Class - {761497BB-D6F0-462C-B6EB-D4DAF1D92D43} - C:\Program Files\Java\jre1.5.0_06\bin\ssv.dll
O2 - BHO: scriptproxy - {7DB2D5A0-7241-4E79-B68D-6309F01C5231} - C:\Program Files\McAfee\VirusScan Enterprise\scriptsn.dll
O3 - Toolbar: (no name) - {0BF43445-2F28-4351-9252-17FE6E806AA0} - (no file)
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\system32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\system32\hkcmd.exe
O4 - HKLM\..\Run: [Persistence] C:\WINDOWS\system32\igfxpers.exe
O4 - HKLM\..\Run: [SoundMAXPnP] C:\Program Files\Analog Devices\Core\smax4pnp.exe
O4 - HKLM\..\Run: [SoundMAX] "C:\Program Files\Analog Devices\SoundMAX\Smax4.exe" /tray
O4 - HKLM\..\Run: [PDF Complete] C:\Program Files\PDF Complete\pdfsty.exe
O4 - HKLM\..\Run: [SetRefresh] C:\Program Files\Compaq\SetRefresh\SetRefresh.exe
O4 - HKLM\..\Run: [Recguard] C:\WINDOWS\Sminst\Recguard.exe
O4 - HKLM\..\Run: [Reminder] C:\WINDOWS\Creator\Remind_XP.exe
O4 - HKLM\..\Run: [Scheduler] C:\WINDOWS\SMINST\Scheduler.exe
O4 - HKLM\..\Run: [GrooveMonitor] "C:\Program Files\Microsoft Office\Office12\GrooveMonitor.exe"
O4 - HKLM\..\Run: [SunJavaUpdateSched] C:\Program Files\Java\jre1.5.0_06\bin\jusched.exe
O4 - HKLM\..\Run: [Communicator] "C:\Program Files\Microsoft Office Communicator\communicator.exe" /fromrunkey
O4 - HKLM\..\Run: [Malwarebytes Anti-Malware (reboot)] "C:\Program Files\Malwarebytes' Anti-Malware\mbam.exe" /runcleanupscript
O4 - HKLM\..\Run: [ShStatEXE] "C:\Program Files\McAfee\VirusScan Enterprise\SHSTAT.EXE" /STANDALONE
O4 - HKLM\..\Run: [Windows Defender] "C:\Program Files\Windows Defender\MSASCui.exe" -hide
O4 - HKCU\..\Run: [ctfmon.exe] C:\WINDOWS\system32\ctfmon.exe
O4 - HKUS\S-1-5-18\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'SYSTEM')
O4 - HKUS\.DEFAULT\..\Run: [CTFMON.EXE] C:\WINDOWS\system32\CTFMON.EXE (User 'Default user')
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\Office12\EXCEL.EXE/3000
O9 - Extra button: (no name) - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.5.0_06\bin\ssv.dll
O9 - Extra 'Tools' menuitem: Sun Java Console - {08B0E5C0-4FCB-11CF-AAA5-00401C608501} - C:\Program Files\Java\jre1.5.0_06\bin\ssv.dll
O9 - Extra button: Send to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra 'Tools' menuitem: S&end to OneNote - {2670000A-7350-4f3c-8081-5663EE0C6C49} - C:\PROGRA~1\MICROS~2\Office12\ONBttnIE.dll
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\Office12\REFIEBAR.DLL
O9 - Extra button: (no name) - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra 'Tools' menuitem: @xpsp3res.dll,-20001 - {e2e2dd38-d088-4134-82b7-f2ba38496583} - C:\WINDOWS\Network Diagnostic\xpnetdiag.exe
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O14 - IERESET.INF: START_PAGE_URL=http://ie.redirect.hp.com/svs/rdr?TYPE=3&tp=iehome&locale=en_gb&c=91&bd=all&pf=cmdt
O15 - Trusted Zone: http://*.isd.icscomputing.co.uk
O15 - Trusted Zone: http://intranet.isd.icscomputing.co.uk
O15 - Trusted Zone: http://*.isd.icscomputing.co.uk (HKLM)
O15 - Trusted Zone: http://intranet.isd.icscomputing.co.uk (HKLM)
O16 - DPF: {215B8138-A3CF-44C5-803F-8226143CFC0A} (Trend Micro ActiveX Scan Agent 6.6) - http://housecall65.trendmicro.com/housecall/applet/html/native/x86/win32/activex/hcImpl.cab
O16 - DPF: {6414512B-B978-451D-A0D8-FCFDF33E833C} (WUWebControl Class) - http://update.microsoft.com/windowsupdate/v6/V5Controls/en/x86/client/wuweb_site.cab?1252427971625
O16 - DPF: {D27CDB6E-AE6D-11CF-96B8-444553540000} (Shockwave Flash Object) - http://fpdownload2.macromedia.com/get/s ... wflash.cab
O17 - HKLM\System\CCS\Services\Tcpip\Parameters: Domain = isd.icscomputing.co.uk
O17 - HKLM\Software\..\Telephony: DomainName = isd.icscomputing.co.uk
O17 - HKLM\System\CS1\Services\Tcpip\Parameters: Domain = isd.icscomputing.co.uk
O17 - HKLM\System\CS2\Services\Tcpip\Parameters: Domain = isd.icscomputing.co.uk
O18 - Protocol: grooveLocalGWS - {88FED34C-F0CA-4636-A375-3CB6248B04CD} - C:\Program Files\Microsoft Office\Office12\GrooveSystemServices.dll
O23 - Service: McAfee Application Installer Cleanup (0002531252378597) (0002531252378597mcinstcleanup) - Unknown owner - C:\DOCUME~1\ADMINI~1\LOCALS~1\Temp\000253~1.EXE (file missing)
O23 - Service: ActiveWorkflow Job Scheduler (AWJobScheduler) - Singularity Limited - C:\Program Files\ProcessPlatform\AwJobScheduler.exe
O23 - Service: ActiveWorkflow Monitoring (AWMonitorAndDownloadAgent) - Singularity Limited - C:\Program Files\ProcessPlatform\AWMonitoring.exe
O23 - Service: ActiveWorkflow Process Work (AWProcessWorkAgent) - Singularity Limited - C:\Program Files\ProcessPlatform\AWProcessWork.exe
O23 - Service: ActiveWorkflow Resources (AWResourcesAgent) - Singularity Limited - C:\Program Files\ProcessPlatform\AWResources.exe
O23 - Service: InstallDriver Table Manager (IDriverT) - Macrovision Corporation - C:\Program Files\Common Files\InstallShield\Driver\11\Intel 32\IDriverT.exe
O23 - Service: IviRegMgr - InterVideo - C:\Program Files\Common Files\InterVideo\RegMgr\iviRegMgr.exe
O23 - Service: McAfee Engine Service (McAfeeEngineService) - McAfee, Inc. - C:\Program Files\McAfee\VirusScan Enterprise\EngineServer.exe
O23 - Service: McAfee Framework Service (McAfeeFramework) - McAfee, Inc. - C:\Program Files\McAfee\Common Framework\FrameworkService.exe
O23 - Service: McAfee McShield (McShield) - McAfee, Inc. - C:\Program Files\McAfee\VirusScan Enterprise\Mcshield.exe
O23 - Service: McAfee Task Manager (McTaskManager) - McAfee, Inc. - C:\Program Files\McAfee\VirusScan Enterprise\VsTskMgr.exe
O23 - Service: McAfee Validation Trust Protection Service (mfevtp) - McAfee, Inc. - C:\WINDOWS\system32\mfevtps.exe
O23 - Service: PC Angel (PCA) - SoftThinks - C:\WINDOWS\SMINST\PCAngel.exe
O23 - Service: PDF Document Manager (pdfcDispatcher) - PDF Complete Inc - C:\Program Files\PDF Complete\pdfsvc.exe

--
End of file - 9040 bytes

Thanks for your help.

Hi jpcoffey,

I have examined your log, and I believe this to be a computer used for business, either personal or corporate.
If I could point you in the direction of our rules, which state under IF YOU NEED HELP:

We do not help in cleaning business or corporate computers. There may be restrictions and modifications installed on such machines that could be damaged or altered by the actions we take to remove Malware. There may also be legal issues regarding any loss of business data that we do not wish to deal with.
If you ask for help and, unknown to us, it involves a business computer, you need to understand that any damages resulting from our advice are YOUR RESPONSIBILITY.

http://www.malwareremoval.com/rules.php

If this is indeed a business computer:

• If it is a corporate computer, it is suggested that you take this issue to your IT department.
• If this is a personal computer used for business (personal or corporate), it is suggested that you take this issue to your IT department, or your local PC repair store.
• Please let me know you have read this so that the topic can be closed. I am sorry I can not be of further assistance.
• Thank you for your understanding.

If my conclusion is incorrect about the use of the machine, please let me know in your next post.
askey127

Ok, you can close it then. Thanks anyway.