My inlaws comp has been infected, 1st thing she noticed was that her Outlook Express email wouldn't send, I ran a few removal tools on it, the message is popping up almost every mouse click. Here is the log file, hope you can help restore peace and traquility on her comp. 
Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 4:45:08 PM, on 3/16/2008
Platform: Windows XP SP2 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)
Boot mode: Normal
Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\Program Files\Common Files\Symantec Shared\ccSetMgr.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
C:\Program Files\Common Files\Symantec Shared\ccProxy.exe
C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe
C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
C:\Program Files\Common Files\Symantec Shared\SPBBC\SPBBCSvc.exe
C:\Program Files\Common Files\Symantec Shared\CCPD-LC\symlcsvc.exe
C:\Program Files\Lavasoft\Ad-Aware 2007\aawservice.exe
C:\WINDOWS\system32\spoolsv.exe
C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
C:\Program Files\Norton Internet Security\Norton AntiVirus\navapsvc.exe
C:\WINDOWS\system32\oodag.exe
C:\Program Files\Common Files\New Boundary\PrismXL\PRISMXL.SYS
C:\WINDOWS\system32\igfxtray.exe
C:\WINDOWS\system32\hkcmd.exe
C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb05.exe
C:\Program Files\Common Files\Symantec Shared\ccApp.exe
C:\WINDOWS\system32\igfxpers.exe
C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkCalRem.exe
C:\WINDOWS\system32\msiexec.exe
C:\WINDOWS\system32\wuauclt.exe
C:\Program Files\Common Files\Symantec Shared\Security Console\NSCSRVCE.EXE
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\DL's\HJTInstall.exe
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe
C:\Program Files\Messenger\msmsgs.exe
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.comcast.net/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.comcast.net/
R1 - HKCU\Software\Microsoft\Internet Connection Wizard,ShellNext = http://www.emachines.com/
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyServer = :0
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: Norton Internet Security 2006 - {9ECB9560-04F9-4bbc-943D-298DDF1699E1} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O2 - BHO: NAV Helper - {A8F38D8D-E480-4D52-B7A2-731BB6995FDD} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O2 - BHO: Windows Media Player - {C7E9503C-DA29-4183-8FA9-978C32852C20} - C:\WINDOWS\wmpdxm.dll
O3 - Toolbar: Norton Internet Security 2006 - {0B53EAC3-8D69-4b9e-9B19-A37C9A5676A7} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O3 - Toolbar: Norton AntiVirus - {C4069E3A-68F1-403E-B40E-20066696354B} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\system32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\system32\hkcmd.exe
O4 - HKLM\..\Run: [Recguard] %WINDIR%\SMINST\RECGUARD.EXE
O4 - HKLM\..\Run: [HPDJ Taskbar Utility] C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb05.exe
O4 - HKLM\..\Run: [tgcmd] "C:\Program Files\support.com\bin\tgcmd.exe" /server
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [Persistence] C:\WINDOWS\system32\igfxpers.exe
O4 - HKLM\..\Run: [Symantec PIF AlertEng] "C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe" /a /m "C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\AlertEng.dll"
O4 - HKCU\..\Run: [updateMgr] C:\Program Files\Adobe\Acrobat 7.0\Reader\AdobeUpdateManager.exe AcRdB7_0_9
O4 - Startup: WkCalRem.LNK = C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkCalRem.exe
O4 - Global Startup: BigFix.lnk = C:\Program Files\BigFix\BigFix.exe
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\OFFICE11\EXCEL.EXE/3000
O9 - Extra button: ComcastHSI - {669B269B-0D4E-41FB-A3D8-FD67CA94F646} - http://www.comcast.net/ (file missing)
O9 - Extra button: Support - {8828075D-D097-4055-AA02-2DBFA9D85E8A} - http://www.comcastsupport.com/ (file missing)
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\OFFICE11\REFIEBAR.DLL
O9 - Extra button: Help - {97809617-3937-4F84-B335-9BB05EF1A8D4} - http://online.comcast.net/help/ (file missing)
O9 - Extra button: Real.com - {CD67F990-D8E9-11d2-98FE-00C0F0318AFE} - C:\WINDOWS\system32\Shdocvw.dll
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O16 - DPF: {406B5949-7190-4245-91A9-30A17DE16AD0} (Snapfish Activia) - http://photo.walgreens.com/WalgreensActivia.cab
O16 - DPF: {6414512B-B978-451D-A0D8-FCFDF33E833C} (WUWebControl Class) - http://update.microsoft.com/windowsupdate/v6/V5Controls/en/x86/client/wuweb_site.cab?1142207058000
O23 - Service: Ad-Aware 2007 Service (aawservice) - Lavasoft - C:\Program Files\Lavasoft\Ad-Aware 2007\aawservice.exe
O23 - Service: Automatic LiveUpdate Scheduler - Symantec Corporation - C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Internet Security Password Validation (ccISPwdSvc) - Symantec Corporation - C:\Program Files\Norton Internet Security\ccPwdSvc.exe
O23 - Service: Symantec Network Proxy (ccProxy) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccProxy.exe
O23 - Service: Symantec Settings Manager (ccSetMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccSetMgr.exe
O23 - Service: COM Host (comHost) - Symantec Corporation - C:\Program Files\Norton Internet Security\comHost.exe
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: LiveUpdate Notice Service - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe
O23 - Service: Norton AntiVirus Auto-Protect Service (navapsvc) - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\navapsvc.exe
O23 - Service: Norton Protection Center Service (NSCService) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\Security Console\NSCSRVCE.EXE
O23 - Service: O&O Defrag - O&O Software GmbH - C:\WINDOWS\system32\oodag.exe
O23 - Service: PrismXL - New Boundary Technologies, Inc. - C:\Program Files\Common Files\New Boundary\PrismXL\PRISMXL.SYS
O23 - Service: Symantec AVScan (SAVScan) - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\SAVScan.exe
O23 - Service: Symantec Network Drivers Service (SNDSrvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
O23 - Service: Symantec SPBBCSvc (SPBBCSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SPBBC\SPBBCSvc.exe
O23 - Service: Symantec Core LC - Unknown owner - C:\Program Files\Common Files\Symantec Shared\CCPD-LC\symlcsvc.exe
--
End of file - 7993 bytes
Logfile of Trend Micro HijackThis v2.0.2
Scan saved at 4:45:08 PM, on 3/16/2008
Platform: Windows XP SP2 (WinNT 5.01.2600)
MSIE: Internet Explorer v6.00 SP2 (6.00.2900.2180)
Boot mode: Normal
Running processes:
C:\WINDOWS\System32\smss.exe
C:\WINDOWS\system32\winlogon.exe
C:\WINDOWS\system32\services.exe
C:\WINDOWS\system32\lsass.exe
C:\WINDOWS\system32\svchost.exe
C:\WINDOWS\System32\svchost.exe
C:\Program Files\Common Files\Symantec Shared\ccSetMgr.exe
C:\WINDOWS\Explorer.EXE
C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
C:\Program Files\Common Files\Symantec Shared\ccProxy.exe
C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe
C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
C:\Program Files\Common Files\Symantec Shared\SPBBC\SPBBCSvc.exe
C:\Program Files\Common Files\Symantec Shared\CCPD-LC\symlcsvc.exe
C:\Program Files\Lavasoft\Ad-Aware 2007\aawservice.exe
C:\WINDOWS\system32\spoolsv.exe
C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
C:\Program Files\Norton Internet Security\Norton AntiVirus\navapsvc.exe
C:\WINDOWS\system32\oodag.exe
C:\Program Files\Common Files\New Boundary\PrismXL\PRISMXL.SYS
C:\WINDOWS\system32\igfxtray.exe
C:\WINDOWS\system32\hkcmd.exe
C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb05.exe
C:\Program Files\Common Files\Symantec Shared\ccApp.exe
C:\WINDOWS\system32\igfxpers.exe
C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkCalRem.exe
C:\WINDOWS\system32\msiexec.exe
C:\WINDOWS\system32\wuauclt.exe
C:\Program Files\Common Files\Symantec Shared\Security Console\NSCSRVCE.EXE
C:\Program Files\Internet Explorer\IEXPLORE.EXE
C:\DL's\HJTInstall.exe
C:\Program Files\Trend Micro\HijackThis\HijackThis.exe
C:\Program Files\Messenger\msmsgs.exe
R0 - HKCU\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.comcast.net/
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Page_URL = http://go.microsoft.com/fwlink/?LinkId=69157
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Default_Search_URL = http://go.microsoft.com/fwlink/?LinkId=54896
R1 - HKLM\Software\Microsoft\Internet Explorer\Main,Search Page = http://go.microsoft.com/fwlink/?LinkId=54896
R0 - HKLM\Software\Microsoft\Internet Explorer\Main,Start Page = http://www.comcast.net/
R1 - HKCU\Software\Microsoft\Internet Connection Wizard,ShellNext = http://www.emachines.com/
R1 - HKCU\Software\Microsoft\Windows\CurrentVersion\Internet Settings,ProxyServer = :0
O2 - BHO: Adobe PDF Reader Link Helper - {06849E9F-C8D7-4D59-B87D-784B7D6BE0B3} - C:\Program Files\Adobe\Acrobat 7.0\ActiveX\AcroIEHelper.dll
O2 - BHO: Norton Internet Security 2006 - {9ECB9560-04F9-4bbc-943D-298DDF1699E1} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O2 - BHO: NAV Helper - {A8F38D8D-E480-4D52-B7A2-731BB6995FDD} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O2 - BHO: Windows Media Player - {C7E9503C-DA29-4183-8FA9-978C32852C20} - C:\WINDOWS\wmpdxm.dll
O3 - Toolbar: Norton Internet Security 2006 - {0B53EAC3-8D69-4b9e-9B19-A37C9A5676A7} - C:\Program Files\Common Files\Symantec Shared\AdBlocking\NISShExt.dll
O3 - Toolbar: Norton AntiVirus - {C4069E3A-68F1-403E-B40E-20066696354B} - C:\Program Files\Norton Internet Security\Norton AntiVirus\NavShExt.dll
O4 - HKLM\..\Run: [QuickTime Task] "C:\Program Files\QuickTime\qttask.exe" -atboottime
O4 - HKLM\..\Run: [IgfxTray] C:\WINDOWS\system32\igfxtray.exe
O4 - HKLM\..\Run: [HotKeysCmds] C:\WINDOWS\system32\hkcmd.exe
O4 - HKLM\..\Run: [Recguard] %WINDIR%\SMINST\RECGUARD.EXE
O4 - HKLM\..\Run: [HPDJ Taskbar Utility] C:\WINDOWS\system32\spool\drivers\w32x86\3\hpztsb05.exe
O4 - HKLM\..\Run: [tgcmd] "C:\Program Files\support.com\bin\tgcmd.exe" /server
O4 - HKLM\..\Run: [ccApp] "C:\Program Files\Common Files\Symantec Shared\ccApp.exe"
O4 - HKLM\..\Run: [Persistence] C:\WINDOWS\system32\igfxpers.exe
O4 - HKLM\..\Run: [Symantec PIF AlertEng] "C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe" /a /m "C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\AlertEng.dll"
O4 - HKCU\..\Run: [updateMgr] C:\Program Files\Adobe\Acrobat 7.0\Reader\AdobeUpdateManager.exe AcRdB7_0_9
O4 - Startup: WkCalRem.LNK = C:\Program Files\Common Files\Microsoft Shared\Works Shared\WkCalRem.exe
O4 - Global Startup: BigFix.lnk = C:\Program Files\BigFix\BigFix.exe
O8 - Extra context menu item: E&xport to Microsoft Excel - res://C:\PROGRA~1\MICROS~2\OFFICE11\EXCEL.EXE/3000
O9 - Extra button: ComcastHSI - {669B269B-0D4E-41FB-A3D8-FD67CA94F646} - http://www.comcast.net/ (file missing)
O9 - Extra button: Support - {8828075D-D097-4055-AA02-2DBFA9D85E8A} - http://www.comcastsupport.com/ (file missing)
O9 - Extra button: Research - {92780B25-18CC-41C8-B9BE-3C9C571A8263} - C:\PROGRA~1\MICROS~2\OFFICE11\REFIEBAR.DLL
O9 - Extra button: Help - {97809617-3937-4F84-B335-9BB05EF1A8D4} - http://online.comcast.net/help/ (file missing)
O9 - Extra button: Real.com - {CD67F990-D8E9-11d2-98FE-00C0F0318AFE} - C:\WINDOWS\system32\Shdocvw.dll
O9 - Extra button: Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O9 - Extra 'Tools' menuitem: Windows Messenger - {FB5F1910-F110-11d2-BB9E-00C04F795683} - C:\Program Files\Messenger\msmsgs.exe
O16 - DPF: {406B5949-7190-4245-91A9-30A17DE16AD0} (Snapfish Activia) - http://photo.walgreens.com/WalgreensActivia.cab
O16 - DPF: {6414512B-B978-451D-A0D8-FCFDF33E833C} (WUWebControl Class) - http://update.microsoft.com/windowsupdate/v6/V5Controls/en/x86/client/wuweb_site.cab?1142207058000
O23 - Service: Ad-Aware 2007 Service (aawservice) - Lavasoft - C:\Program Files\Lavasoft\Ad-Aware 2007\aawservice.exe
O23 - Service: Automatic LiveUpdate Scheduler - Symantec Corporation - C:\Program Files\Symantec\LiveUpdate\ALUSchedulerSvc.exe
O23 - Service: Symantec Event Manager (ccEvtMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccEvtMgr.exe
O23 - Service: Symantec Internet Security Password Validation (ccISPwdSvc) - Symantec Corporation - C:\Program Files\Norton Internet Security\ccPwdSvc.exe
O23 - Service: Symantec Network Proxy (ccProxy) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccProxy.exe
O23 - Service: Symantec Settings Manager (ccSetMgr) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\ccSetMgr.exe
O23 - Service: COM Host (comHost) - Symantec Corporation - C:\Program Files\Norton Internet Security\comHost.exe
O23 - Service: LiveUpdate - Symantec Corporation - C:\PROGRA~1\Symantec\LIVEUP~1\LUCOMS~1.EXE
O23 - Service: LiveUpdate Notice Service - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\PIF\{B8E1DD85-8582-4c61-B58F-2F227FCA9A08}\PIFSvc.exe
O23 - Service: Norton AntiVirus Auto-Protect Service (navapsvc) - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\navapsvc.exe
O23 - Service: Norton Protection Center Service (NSCService) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\Security Console\NSCSRVCE.EXE
O23 - Service: O&O Defrag - O&O Software GmbH - C:\WINDOWS\system32\oodag.exe
O23 - Service: PrismXL - New Boundary Technologies, Inc. - C:\Program Files\Common Files\New Boundary\PrismXL\PRISMXL.SYS
O23 - Service: Symantec AVScan (SAVScan) - Symantec Corporation - C:\Program Files\Norton Internet Security\Norton AntiVirus\SAVScan.exe
O23 - Service: Symantec Network Drivers Service (SNDSrvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SNDSrvc.exe
O23 - Service: Symantec SPBBCSvc (SPBBCSvc) - Symantec Corporation - C:\Program Files\Common Files\Symantec Shared\SPBBC\SPBBCSvc.exe
O23 - Service: Symantec Core LC - Unknown owner - C:\Program Files\Common Files\Symantec Shared\CCPD-LC\symlcsvc.exe
--
End of file - 7993 bytes
