Malware Infection, Overwhelming Popups, LuckYaShoppper

MDSteg,
If you open OTL one more time, and click the CleanUp button it will remove itself and the quarantined items.

Your Symantec Endpoint and Malwarebytes are quite adequate as a virus and malware protection.

I would suggest the following to keep it quick:
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Download and Run Temp File Cleaner (TFC.exe)
Download Temp File Cleaner and save it to your desktop.
You might want to Save any unsaved work. TFC will close ALL open programs... including your browser!
Right click the TFC icon and choose Run as administrator.
If you have a lot of junk files to remove, it could take a while, so please be patient and let it finish.
When it's done, it will report the total size of files removed. If it asks to Reboot, choose to do so. This will remove files that could not be removed while Windows was running.
After Restart, log back in to your usual account.
You can keep TFC on your desktop and run it every week or two to clean out excessive temporary files. It does usually require a restart.
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Download MyDefrag from here and Install it : http://www.mydefrag.com/
(The download button is on the left).
After Installation, run MyDefrag in System Disk Monthly Mode on the C: drive
(Click System Disk Monthly and then check C: drive, click Run)
Wait for it. It goes through 6 Zones. The Window will be labeled Finished at the top when it is done.
Going forward, you can run it in System Disk Daily mode, but once every week or two is sufficient.
It will finish quite a bit faster in the ensuing runs.

Good luck !
askey127

Thanks for all your help! This is much appreciated!